The purpose of the study is to investigate the relationship between organisational leadership, organisational performance and innovation among small and medium-sized businesses (SMEs) in Ghana. We hypothesize organisational leadership as a mediator between innovation and organisational performance. Thus, we investigated how innovation and organisational leadership directly influence organisational success. The study uses quantitative methodology and adopts a survey approach to collect data from SMEs (n=380) in Ghana. The results indicate that organisational leadership and performance are positively correlated. Further, we found that organisational leadership within SMEs affects the relationship between innovation and organisational performance. By identifying the positive effects of innovation and organisational leadership on organisational performance, this study encourages SMEs to invest in innovation and develop strong leadership capabilities.