Sustainable development increasingly depends on institutions operating below the national level, yet the combined contribution of municipalities, universities and enterprises has received comparatively limited attention in the African policy literature. This article examines how local tri-sector partnerships can support sustainable development, with particular reference to Africa-Europe cooperation. Drawing on the Triple Helix model and on scholarship concerning networked and polycentric governance, it sets out a basis for assessing when such partnerships add value, and applies it to four cases: sanitation and resource recovery in Nakuru County, Kenya; municipal data capability in Cape Town, South Africa; water innovation in Murcia, Spain; and the intercontinental AU-EU Digital for Development Hub. The cases suggest that the contribution of tri-sector collaboration lies less in shared functions than in the way each partner occupies a different part of the implementation chain. They also indicate that transferability is limited: design principles travel, whereas governance arrangements, financing and technologies require adaptation to local law, capacity and political economy. The article identifies structural constraints, partnership-level risks-notably power asymmetries and short funding cycles-and the conditions associated with more durable arrangements. It concludes that local partnerships are more likely to extend public capacity where capable institutions, coherent policy and democratic accountability are already in place.